Ghatpande, A. S. ; Sikdar, S. K. (1999) Voltage dependent gating of veratridine modified RIIA Na+channel α-subunit expressed heterologously in CHO cells Pflügers Archiv European Journal of Physiology, 438 (3). pp. 378-383. ISSN 0031-6768
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Official URL: http://www.springerlink.com/content/h50clpt6du5d3p...
Related URL: http://dx.doi.org/10.1007/s004240050924
Abstract
The voltage-dependent kinetics of veratridine-modified RIIA Na+ channel a subunit expressed heterologously in CHO cells were studied using the whole-cell patch-clamp technique. The activation and deactivation kinetics are well described by double exponential functions but poorly by a monoexponential function. Unlike the slow component, the fast time constant and associated amplitude factor depended steeply on the potential. The steady-state activation of veratridine-modified channels is described by a Boltzmann function with a V ½ of -131.9 mV and a slope of 9.41 mV. A two-state model is proposed for the fast component that explains the kinetics of veratridine's mechanism of action.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer. |
| Keywords: | Kinetic Analysis; Patch Clamp; RIIA Sodium Channel α Subunit; Veratridine-induced Modification |
| ID Code: | 90228 |
| Deposited On: | 07 May 2012 13:26 |
| Last Modified: | 07 May 2012 13:26 |
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