Yin, Yifeng ; Gokhale, Rajesh ; Khosla, Chaitan ; Cane, David E. (2001) Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase Bioorganic & Medicinal Chemistry Letters, 11 (12). pp. 1477-1479. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0960-894X(00)00529-1
Abstract
Incubation of chirally deuterated NADPH with 6-deoxyerythronolide B synthase (DEBS) modules 5 and module 6 and analysis of the derived triketide lactones established that the two ketoreductase domains, KR5 and KR6, are both specific for the 4-pro-S hydride of the nicotinamide cofactor.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 90144 |
| Deposited On: | 07 May 2012 11:52 |
| Last Modified: | 07 May 2012 11:52 |
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