Marsh, D. G. ; Neely, J. D. ; Breazeale, D. R. ; Ghosh, B. ; Freidhoff, L. R. ; Ehrlich-Kautzky, E. ; Schou, C. ; Krishnaswamy, G. ; Beaty, T. H. (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations Science, 264 (5162). pp. 1152-1156. ISSN 0036-8075
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Official URL: http://www.sciencemag.org/content/264/5162/1152.sh...
Related URL: http://dx.doi.org/10.1126/science.8178175
Abstract
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 89938 |
| Deposited On: | 02 May 2012 13:27 |
| Last Modified: | 02 May 2012 13:27 |
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