Batra, J. ; Sharma, M. ; Chatterjee, R. ; Sharma, S. ; Mabalirajan, U. ; Ghosh, B. (2005) CCR5 Δ 32 deletion and atopic asthma in India Thorax, 60 . p. 85. ISSN 0040-6376
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Official URL: http://thorax.bmj.com/content/60/1/85.2.extract
Abstract
Chemokine receptor 5 (CCR5) contributes to the generation of a Th1 immune response by interacting with agonists such as RANTES, MIP-1α , and MIP-1β .1 A 32 base pair deletion (Δ 32) in CCR5 has been proposed to protect individuals against HIV infection and to bias the immune system towards a Th2-driven response, thus affecting the susceptibility to develop allergic diseases such as asthma. In a study in Scottish children, Hall et al reported an association of CCR5Δ 32 with a reduced risk of asthma2 but found.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to BMJ Publishing Group. |
| ID Code: | 89931 |
| Deposited On: | 02 May 2012 13:28 |
| Last Modified: | 02 May 2012 13:28 |
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