Malhotra, Shashwat ; Balwani, Sakshi ; Dhawan, Ashish ; Singh, Brajendra K. ; Kumar, Sarvesh ; Thimmulappa, Rajesh ; Biswal, Shyam ; Olsen, Carl E. ; Eycken, Erik Van der ; Prasad, Ashok K. ; Ghosh, Balaram ; Parmar, Virinder S. (2011) Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells Medicinal chemistry communications, 2 (8). pp. 743-751. ISSN 2040-2511
Full text not available from this repository.
Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2011...
Related URL: http://dx.doi.org/10.1039/C0MD00262C
Abstract
Novel N-protected derivatives of substituted isatins have been synthesized and evaluated for their potency in inhibiting TNF-α-induced ICAM-1 activity on human endothelial cells as a marker for anti-inflammatory activity. Compound 3p was found to be most potent in inhibiting the ICAM-1 expression in a concentration- and time-dependent manner. The structure-activity relationship of these compounds in inhibiting ICAM-1 expression activity is elucidated in the present study.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemsitry. |
| ID Code: | 89924 |
| Deposited On: | 02 May 2012 13:34 |
| Last Modified: | 02 May 2012 13:34 |
Repository Staff Only: item control page
