Sad, S. ; Rao, K. ; Arora, R. ; Talwar, G. P. ; Raghupathy, R. (1992) Bypass of carrier-induced epitope-specific suppression using a T-helper epitope Immunology, 76 (4). pp. 599-603. ISSN 0019-2805
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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/%28...
Abstract
A gonadotropin-releasing hormone (GnRH)-based vaccine is being developed as a method for non-surgical immunotherapy as immunization with this vaccine results in atrophy of the prostate. This vaccine, a conjugate of GnRH and diphtheria toxoid (DT), provides a unique hapten-carrier system for investigating the influence of carrier presensitization on antibody responses to self haptens. In a recent communication we showed that preimmunization with carriers diphtheria toxoid and tetanus toxoid results in a strain-dependent inhibition of anti-GnRH responses in mice and that T cells from carrier-presensitized mice are responsible for anti-haptenic suppression. In the present report we describe a strategy for bypassing DT-induced epitopic suppression using a T-helper epitope from DT.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons. |
ID Code: | 89704 |
Deposited On: | 30 Apr 2012 14:36 |
Last Modified: | 30 Apr 2012 14:36 |
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