Hazra, A. K. ; Batra, J. K. ; Raj, H. G. ; Venkitasurbamanian, T. A. (1980) Changes in hepatic polyamine levels during acute and chronic administration of aflatoxin B1 to rats Toxicon, 18 (2). pp. 209-213. ISSN 0041-0101
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0041-0101(80)90075-6
Abstract
A subacute dose of aflatoxin B1 (3 mg/kg body weight) increases liver putrescine levels within 1 hr after administration, with high levels persisting over 24 hr. Higher doses of the carcinogen elicited larger increases in liver polyaminelevels. A marked elevation of putrescine, spermidine and spermine were noted in aflatoxin B1-induced preneoplastic liver. Pretreatment of rats with phenobarbital prior to aflatoxin B1administration resulted in no synergistic or additive effects.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 88899 |
| Deposited On: | 30 Mar 2012 06:43 |
| Last Modified: | 30 Mar 2012 06:43 |
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