Chattopadhyay, Subrata ; Pal, Saumen ; Pal, Debashis ; Sarkar, Dibyendu ; Chandra, Suparna ; Das Gupta, Chanchal (1999) Protein folding in Escherichia coli: role of 23S ribosomal RNA Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1429 (2). pp. 293-298. ISSN 0167-4838
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01674...
Related URL: http://dx.doi.org/10.1016/S0167-4838(98)00179-4
Abstract
Post-translational control of Escherichia coli ribosome on newly synthesised polypeptide leading to its active conformation (protein folding) has been shown in the case of the enzyme β-galactosidase. As expected, antibiotics chloramphenicol and lincomycin, which bind to 23S rRNA/50S subunit and kasugamycin and streptomycin which interact with the 30S subunit instantaneously inhibited protein synthesis when they were added to the growing cells. The increase in β-galactosidase activity, though stopped immediately after the addition of chloramphenicol and lincomycin, went on considerably in the presence of streptomycin and kasugamycin even after the stoppage of protein synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Protein Folding; Ribosomal RNA; Chloramphenicol; Lincomycin |
| ID Code: | 8869 |
| Deposited On: | 28 Oct 2010 10:42 |
| Last Modified: | 28 May 2011 09:18 |
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