Joshi, A. R. ; Sinha, S. ; Dil-Afroz, ; Sulaiman, I. M. ; Banerji, A. K. ; Hasnain, S. E. (1996) Alterations in brain tumor DNA detected by a fingerprinting probe Indian Journal of Biochemistry & Biophysics, 33 (6). pp. 455-457. ISSN 0301-1208
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Abstract
We used a novel DNA fingerprinting probe O-chi-1 (ref. 1) to detect differences in the hybridization pattern of brain tumor DNA and paired normal tissue of a given individual. Representatives of meningiomas (two), glioblastoma multeforme (three) and astrocytoma (one) were studied. Alterations, which included amplification as well as the loss of a normal band in tumor DNA, were observed in four of the six tumours. While the increased intensity of a band can be taken to imply increased copy number, the disappearance of bands could either be due to loss of DNA sequence or rearrangement resulting in different sized bands.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| ID Code: | 88610 |
| Deposited On: | 29 Mar 2012 09:34 |
| Last Modified: | 15 Jul 2012 09:44 |
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