Initiation of ovulation and regulation of Luteal function

Abstract

An attempt has been made in the present paper to review the current status of our knowledge on the subject of relative role of Luteinzing Hormone (LH) and Follicle Stimulating Hormone (FSH) in the initiation of ovolution and regulation of luteal function. Emphasis is laid on studies in laboratory rodents and primates and work from our laboratory and others are reviewed. The use of specific, well-characterized anti-gonadotropins in delineating the the role of LH and FSH in these has been highlighted. Evidence has been furnished in support of LH being the true physiological trigger for ovulation to occur. Data in support of the concept that both prolactin and LH are needed to maintain luteal function is furnished; the former responsible for providing adequate substrate stores as well as maintain a basic cell matrix needed for active steroidogenesis, while the latter regulates the quantum of steroid syhthesis by amplification of the signal.