Das, Aditi ; Dasgupta, Arindam ; Sengupta, Tanushri ; Majumder, Hemanta K. (2004) Topoisomerases of kinetoplastid parasites as potential chemotherapeutic targets Trends in Parasitology, 20 (8). pp. 381-387. ISSN 1471-4922
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.pt.2004.06.005
Abstract
The protozoan parasites Trypanosoma, Leishmania and Crithidia, which belong to the order kinetoplastidae, emerge from the most ancient eukaryotic lineages. The diversity found in the life cycle of these organisms must be directed by genetic events, wherein topoisomerases play an important role in cellular processes affecting the topology and organization of intracellular DNA. Topoisomerases are valuable as potential drug targets because they have indispensable function in cell biology. This review summarizes what is known about topoisomerase genes and proteins of kinetoplastid parasites and the roles of these enzymes as targets for therapeutic agents.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 87832 |
| Deposited On: | 22 Mar 2012 07:52 |
| Last Modified: | 22 Mar 2012 07:52 |
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