Chandrasekhar, Vadapalli ; Deria, Pravas ; Krishnan, Venkatasubbaiah ; Athimoolam, Arunachalampillai ; Singh, Sanjay ; Madhavaiah, C. ; Srivatsan, S. G. ; Verma, Sandeep (2004) Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification Bioorganic & Medicinal Chemistry Letters, 14 (6). pp. 1559-1562. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2003.12.082
Abstract
Pendant pyrazolylcyclophosphazene containing hybrid cross-linked polymer (CPPL) has been utilized for binding Zn(II). The metalated polymer (CPPL-Zn) has been found to be very effective catalyst for the hydrolysis of a RNA model phosphodiester substrate [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP]. In addition, CPPL-Zn also cleaved supercoiled plasmid DNA pBR322 thus providing a novel structural motif of inorganic-organic hybrid polymers as synthetic nucleases. A cyclophosphazene pendant containing cross-linked polymer has been shown to bind to Zn(II); the latter is an effective catalyst for phosphate ester hydrolysis and DNA cleavage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cyclophosphazene; Pendant Polymer; Catalyst; Zinc; Phosphate Ester; Hydrolysis |
| ID Code: | 8783 |
| Deposited On: | 28 Oct 2010 10:51 |
| Last Modified: | 11 Jul 2012 17:48 |
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