Functions and biosynthesis of O-acetylated sialic acids

Mandal, Chitra ; Schwartz-Albiez, Reinhard ; Vlasak, Reinhard (2012) Functions and biosynthesis of O-acetylated sialic acids Topics in Current Chemistry . pp. 1-30. ISSN 0340-1022

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Official URL: http://www.springerlink.com/content/l187123703g213...

Related URL: http://dx.doi.org/10.1007/128_2011_310

Abstract

Sialic acids have a pivotal functional impact in many biological interactions such as virus attachment, cellular adhesion, regulation of proliferation, and apoptosis. A common modification of sialic acids is O-acetylation. O-Acetylated sialic acids occur in bacteria and parasites and are also receptor determinants for a number of viruses. Moreover, they have important functions in embryogenesis, development, and immunological processes. O-Acetylated sialic acids represent cancer markers, as shown for acute lymphoblastic leukemia, and they are known to play significant roles in the regulation of ganglioside-mediated apoptosis. Expression of O-acetylated sialoglycans is regulated by sialic acid-specific O-acetyltransferases and O-acetylesterases. Recent developments in the identification of the enigmatic sialic acid-specific O-acetyltransferase are discussed.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:9-o-acetylated Sialic Acids; Anemia; Anti-9-o-acetylated Sialoglycoprotein Antibody; Apoptosis; Erythrocytes; Indian Visceral Leishmaniasis; Leukemia; O-acetylated Disialoganglioside; O-acetylated Sialoglycoproteins; Sialate O-acetylesterase; Sialate O-acetyltranferase; Sialic Acids
ID Code:87064
Deposited On:14 Mar 2012 14:01
Last Modified:14 Mar 2012 14:01

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