Chatterjee, M. ; Basu, K. ; Basu, D. ; Bannerjee, D. ; Pramanik, N. ; Guha, S. K. ; Goswami, R. P. ; Saha, S. K. ; Mandal, C. (1998) Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients Clinical and Experimental Immunology, 114 (3). pp. 408-413. ISSN 0009-9104
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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...
Related URL: http://dx.doi.org/10.1046/j.1365-2249.1998.00752.x
Abstract
Sodium antimony gluconate (SAG) is the mainstay of treatment for visceral leishmaniasis (VL) or kala-azar. In view of the increasing incidence of refractoriness to SAG in India, we compared the levels of parasite-specific IgG and IgG subclasses in 20 longitudinally followed up kala-azar patients. In both SAG-responsive (n = 10) and unresponsive patients (n = 10), the levels of total IgG, IgG1, IgG2, IgG3 and IgG4 were increased, the rank order being IgG1 > IgG2 > IgG3 = IgG4. Following treatment, a significant decrease in total IgG and the four subclasses occurred in the SAG-responsive group, whereas in the SAG-unresponsive group these levels were unchanged or slightly increased. Therefore, monitoring of IgG1 and IgG2 levels in Indian kala-azar patients is a good serologic alternative to monitoring the disease status.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | IgG Subclasses; Antimonial Unresponsiveness; Kala-azar |
| ID Code: | 87042 |
| Deposited On: | 14 Mar 2012 13:57 |
| Last Modified: | 14 Mar 2012 13:57 |
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