CYP1A1∗2 and CYP1A1∗3 polymorphisms cosegregate in the Indian population

Abstract

Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Two of the CYP1A1 polymorphisms, namely, CYP1A1∗ 2 and CYP1A1∗ 3 are reported to cosegregate among the Japanese and to a lesser extent in Caucasians, but not in people of African descent. In the absence of such information in the Indian population, the frequency of the CYP1A1∗ 2 polymorphism was determined in this study, using DNA samples from 649 ethnic Indians who had been earlier genotyped for the CYP1A1∗ 3 polymorphism. Analysis of the combined genotype data revealed that the two polymorphisms cosegregate in the Indian population.