Mu opioid receptors in developing human spinal cord

Ray, Subrata Basu ; Wadhwa, Shashi (1999) Mu opioid receptors in developing human spinal cord Journal of Anatomy, 195 (1). pp. 11-18. ISSN 0021-8782

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The distribution of mu opioid receptors was studied in human fetal spinal cords between 12-13 and 24-25 wk gestational ages. Autoradiographic localisation using [3H] DAMGO revealed the presence of mu receptors in the dorsal horn at all age groups with a higher density in the superficial laminae (I-II). A biphasic expression was noted. Receptor density increased in the dorsal horn, including the superficial laminae, between 12-13 and 16-17 wk. This could be associated with a spurt in neurogenesis. The density increased again at 24-25 wk in laminae I-II which resembled the adult pattern of distribution. A dramatic proliferation of cells was noted from the region of the ventricular zone between 16-17 and 24-25 wk. These were considered to be glial cells from their histological features. Mu receptor expression was noted over a large area of the spinal cord including the lateral funiculus at 24-25 wk. This may be due to receptor expression by glial cells. The study presents evidence of mu receptor expression by both neurons and glia during early development of human spinal cord.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Neurogenesis; Spinal Cord; Dorsal Horn Laminae; Glial Development
ID Code:86164
Deposited On:08 Mar 2012 07:11
Last Modified:08 Mar 2012 07:11

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