Mohan Kumar, V. ; Sharma, R. ; Wadhwa, S. ; Manchanda, S. K. (1993) Sleep-inducing function of noradrenergic fibers in the medial preoptic area Brain Research Bulletin, 32 (2). pp. 153-158. ISSN 0361-9230
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Abstract
The aim of the investigation was to find out the role of noradrenergic (NE) terminals of the medial preoptic area (mPOA), in the regulation of sleep-wakefulness. Studies were conducted on free-moving adult male rats with chronically implanted cannulae in the mPOA. Sleep-wakefulness was assessed on the basis of EEG, EMG, and EOG recordings along with behavioral observations. Lesioning of catecholamine terminals (with 6-hydroxydopamine) in the mPOA produced an increase in quiet wakefulness. Prevention of NE fiber destruction, by pretreating the rats with imipramine, prevented this effect. This demonstrated that the increased quiet wakefulness produced by 6-OHDA was the result of NE fiber destruction. Changes in sleep-wakefulness were also assessed after microinjection of NE into the mPOA, in normal and ventral noradrenergic bundle (VNA)-lesioned rats. NE administration induced sleep in VNA-lesioned rats, and arousal in normal rats. The findings suggest that the NE terminals in the mPOA, projecting via VNA, play a role in the induction of sleep.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Medial Preoptic Area; Noradrenaline; 6-hydroxydopamine; Sleep-wakefulness; Brain Stem; Catecholamines; Desmethylimipramine |
ID Code: | 86156 |
Deposited On: | 08 Mar 2012 07:08 |
Last Modified: | 08 Mar 2012 07:08 |
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