Singhal, Arun ; Bali, Anu ; Jain, Rakesh K. ; Gupta, C. M. (1984) Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers FEBS Letters, 178 (1). pp. 109-113. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(84)81251-X
Abstract
Incorporation of tuftsin derivatives, Thr-Lys-Pro-Arg-NH-C18H37 or Thr-Lys-Pro-Arg-NH-(CH2)2-NH-COC15H31, into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37° C but not at 0° C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demon-strate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Drug Targeting; Liposome; Ligand-receptor Interaction; Tuftsin; Leukocyte; Endocytosis |
| ID Code: | 85607 |
| Deposited On: | 05 Mar 2012 06:38 |
| Last Modified: | 05 Mar 2012 06:38 |
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