Human milk samples from different ethnic groups contain RNase that inhibits, and plasma membrane that stimulates, reverse transcription

Das, M. R. ; Padhy, L. C. ; Koshy, Rajen ; Sirsat, Satyavati M. ; Rich, Marvin A. (1976) Human milk samples from different ethnic groups contain RNase that inhibits, and plasma membrane that stimulates, reverse transcription Nature, 262 . 802 - 805. ISSN 0028-0836

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Official URL: http://www.nature.com/nature/journal/v262/n5571/ab...

Related URL: http://dx.doi.org/10.1038/262802a0

Abstract

We have compared human milk samples from American, Hindu and Parsi donors with a view to determining the relative amounts of reverse transcriptase inhibitors present in them. Our intention was to find out hether samples from any specific ethnic group are advantageous for the study of type B virus-like particles in milk and for purification of virus-associated enzymes. We also hoped that when sufficient data become available, such studies would be interesting from an epidemiological point of view, to test whether the inhibitors provide protection from mammary cancer. We have confirmed the presence of RNase in milk samples, and have observed variations in the level of RNase in samples from different ethnic groups. Careful examination has also revealed the presence of a protein factor, associated with plasma membranes in milk samples, that stimulates RNA-directed DNA synthesis (RDDS) in vitro in oncornaviruses.

Item Type:Article
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ID Code:8518
Deposited On:27 Oct 2010 06:23
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