Reddy, E. S. ; Das, M. R. ; Reddy, E. P. ; Bhargava, P. M. (1983) Inhibition of reverse transcriptases by seminalplasmin Biochemical Journal, 209 . pp. 183-188. ISSN 0264-6021
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Official URL: http://www.biochemj.org/bj/209/bj2090183.htm
Abstract
Seminalplasmin, an antibacterial protein present in bovine seminal plasma, is shown to be a potent inhibitor of reverse transcriptases (RNA-dependent DNA nucleotidyltransferases). Seminalplasmin inhibits RNA-directed, hybrid-directed, and DNA-directed DNA-polymerizing activities of purified reverse transcriptase from avian myeloblastosis virus and from crude viral lysates of several retroviruses by binding to the enzyme, at least in the case of avian myeloblastosis virus. Seminalplasmin does not inhibit significantly DNA synthesis either by Escherichia coli DNA polymerase I, or a mammalian α-DNA polymerase. The presence of seminalplasmin in the seminal fluid could provide protection to the male and ÷or the female reproductive tract against retroviruses.
Item Type: | Article |
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Source: | Copyright of this article belongs to Portland Press Limited. |
ID Code: | 8517 |
Deposited On: | 27 Oct 2010 06:23 |
Last Modified: | 16 May 2016 18:28 |
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