Aggregation behavior and interaction of an amphiphilic drug imipramine hydrochloride with cationic surfactant cetyltrimethylammonium bromide: light scattering studies

Alam, Md. Sayem ; Ghosh, Goutam ; Mandal, Asit Baran ; Kabir-ud-Din, (2011) Aggregation behavior and interaction of an amphiphilic drug imipramine hydrochloride with cationic surfactant cetyltrimethylammonium bromide: light scattering studies Colloids and Surfaces B: Biointerfaces, 88 (2). pp. 779-784. ISSN 0927-7765

Full text not available from this repository.

Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.colsurfb.2011.08.017

Abstract

The aggregation behavior and interaction of an amphiphilic antidepressant drug imipramine (IMP) hydrochloride with the cationic surfactant cetyltrimethylammonium bromide (CTAB) have been studied using light scattering (both static and dynamic) techniques. Due to rigid tricyclic hydrophobic moiety present in the molecule, the drug shows interesting association behavior. The static light scattering measurements show that the self-association of IMP commenced above a well-defined critical micellar concentration (CMC), which decreases with increasing the mole fraction of the CTAB surfactant. Both the excess Gibbs energy (Δ Gex) and the Gibbs energy of micellization (Δ GM0) are negative, and decrease with increasing mole fraction of the surfactant. The hydrodynamic diameters (dh) of the micellar aggregates were also evaluated using the dynamic light scattering measurements. The data indicate formation of larger aggregates by IMP and CTAB due to mixed micellization and subsequent micellar growth. The results have been analyzed using different models (viz., Clint, Motomura, Rosen, Rubingh, etc.) for mixed micelle formation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Light Scattering; Antidepressant Drug; Imipramine Hydrochloride; Mixed Micelle
ID Code:84383
Deposited On:25 Feb 2012 11:42
Last Modified:25 Feb 2012 11:42

Repository Staff Only: item control page