Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae

Baranwal, Somesh ; Dey, Keya ; Ramamurthy, T. ; Balakrish Nair, G. ; Kundu, Manikuntala (2002) Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae Antimicrobial Agents and Chemotherapy, 46 (8). pp. 2676-2678. ISSN 1098-6596

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Official URL: http://aac.asm.org/content/46/8/2676.abstract

Related URL: http://dx.doi.org/10.1128/AAC.46.8.2676-2678.2002

Abstract

Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:83972
Deposited On:23 Feb 2012 12:53
Last Modified:23 Feb 2012 12:53

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