Sharma, Ashwani ; Sharma, Amit (2011) Fatty acid induced remodeling within the human liver fatty acid-binding protein Journal of Biological Chemistry, 286 . pp. 31924-31928. ISSN 0021-9258
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Official URL: http://www.jbc.org/content/286/36/31924.abstract?s...
Related URL: http://dx.doi.org/10.1074/jbc.M111.270165
Abstract
We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The American Society for Biochemistry and Molecular Biology. |
| Keywords: | Diabetes; Fatty Acid; Fatty Acid-binding Protein; Fatty Acid Metabolism; Fatty Acid Transport; Lipids; Lipid-binding Protein; Obesity |
| ID Code: | 83670 |
| Deposited On: | 22 Feb 2012 05:14 |
| Last Modified: | 22 Feb 2012 05:14 |
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