Vinayak, V. K. ; Chitkara, N. L. ; Chhuttani, P. N. (1979) Effect of corticosteroid and irradiation on caecal amoebic infection in rats Transactions of the Royal Society of Tropical Medicine and Hygiene, 73 (3). pp. 266-268. ISSN 0035-9203
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Official URL: http://www.tropicalmedandhygienejrnl.net/article/0...
Related URL: http://dx.doi.org/10.1016/0035-9203(79)90080-4
Abstract
Albino rats (Wistar strain) were pretreated with corticosteroid, irradiation or both to study the effect on the outcome of amoebic infection given intracaecally. The number of animals with lesions amongst "treated" groups was not significantly different from that amongst untreated control animals (P > 0·05) but amoebic pathology was markedly exacerbated amongst the treated animals. It is thus thought that once the amoebic infection is established, amoebae become better established for penetration in the immuno-depressed host. The study further suggests that corticosteroid therapy could aggravate an otherwise sub-clinical amoebic infection in man.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Tropical Medicine and Hygiene. |
| ID Code: | 8297 |
| Deposited On: | 26 Oct 2010 11:50 |
| Last Modified: | 31 May 2011 05:00 |
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