Chauhan, V. S. ; Pandey, A. V. ; Singh, N. ; Tekwani, B. L. ; Puri, S. K. (1999) Assay of β-hematin formation by malaria parasite Journal of Pharmaceutical and Biomedical Analysis, 20 (1-2). pp. 203-207. ISSN 0731-7085
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S07317...
Related URL: http://dx.doi.org/10.1016/S0731-7085(99)00021-7
Abstract
Novel leads are urgently required for designing antimalarials due to the reduced efficacy of presently available drugs. The malaria parasite has a unique reaction of heme polymerization, which has attracted much attention in the recent past as a target for the design of antimalarial drugs. The process is hampered by non-availability of a proper assay method. Currently available methods are cumbersome and require advanced instrumentation or radioactive substrates. Here, we are describing an assay for hemozoin formation that is simple and reproducible. This assay has routinely been used by us for the identification of potential compounds with antimalarial activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association of Pharmaceutical Scientists. |
| Keywords: | Hemozoin; Malaria; Plasmodium; Hemoglobin; Heme; Chloroquine |
| ID Code: | 8266 |
| Deposited On: | 26 Oct 2010 11:56 |
| Last Modified: | 30 May 2011 11:25 |
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