Tissue imprint imaging by desorption electrospray ionization mass spectrometry

Ifa, Demian R. ; Srimany, Amitava ; Eberlin, Livia S. ; Naik, Hemanta R. ; Bhat, Vasudeva ; Graham Cooks, R. ; Pradeep, T. (2011) Tissue imprint imaging by desorption electrospray ionization mass spectrometry Analytical Methods, 3 (8). pp. 1910-1912. ISSN 1599-1605

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2011...

Related URL: http://dx.doi.org/10.1039/C1AY05295K

Abstract

Cross-sections of Myristica malabarica (Lam) seed and mouse brain tissue were imprinted on such ordinary surfaces as printer paper and TLC plates, and successfully imaged by desorption electrospray ionization mass spectrometry (DESI-MS) at 250 µm resolution. Chemical images representing the distribution of the alkaloid malabaricone C in the seed substructures and individual lipids in the substructures of the brain were obtained. Practical implications include analysis of irregular or soft materials, easy recording, transportation and storage of the latent image, and posterior analysis of the samples by different techniques without the requirement of addition of matrices or use of specific types of surfaces.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:82407
Deposited On:10 Feb 2012 12:54
Last Modified:10 Feb 2012 12:54

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