RNA polymerase and its accessory factors in Escherichia coli

Abstract

RNA polymerase is one of the most important enzymes in living organizms as it controls the synthesis of the key intermediate RNA from DNA message. Regulation of gene expression is primarily governed by the interplay among various protein factors and this enzyme. In this review we tried to emphasize and catalogue all the factors that are known till-date in prokaryotes, taking E., coli as a model. Structural requirements for intricate protein-protein and protein-DNA interaction are also discussed.