Faruque, Shah M. ; Saha, Manujendra N. ; Asadulghani, ; Sack, David A. ; Bradley Sack, R. ; Takeda, Yoshifumi ; Balakrish Nair, G. (2000) The O139 serogroup of Vibrio cholerae comprises diverse clones of epidemic and nonepidemic strains derived from multiple V. cholerae O1 or non-O1 progenitors Journal of Infectious Diseases, 182 (4). pp. 1161-1168. ISSN 0022-1899
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Official URL: http://jid.oxfordjournals.org/content/182/4/1161.a...
Related URL: http://dx.doi.org/10.1086/315807
Abstract
Sixty-four representative strains of Vibrio cholerae O139 were analyzed, to re-examine the origin of this serogroup. Ribotyping differentiated the strains into 3 HindIII and 7 BglI ribotypes. One HindIII and 5 BglI ribotypes were shared by all toxigenic O139 strains. Of 6 nontoxigenic O139 strains, 3 shared ribotypes with the toxigenic strains, carried genes encoding toxin coregulated pilus, and were susceptible to the cholera toxin-converting bacteriophage CTXφ. The remaining 3 strains belonged to 2 different ribotypes distinct from toxigenic O139 strains and were resistant to CTXφ and JA-1, an O139-specific lytic bacteriophage. Polymerase chain reaction amplicons corresponding to the gmhD gene carried by these 3 strains also differed from those of the toxigenic O139 strains but were identical to those of 15 environmental non-O1-non-O139 strains. Thus, the O139 antigen is present in different lineages, and this serogroup appears to comprise epidemic and nonepidemic strains derived separately from different progenitors.
Item Type: | Article |
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Source: | Copyright of this article belongs to University of Chicago Press. |
ID Code: | 82031 |
Deposited On: | 09 Feb 2012 04:30 |
Last Modified: | 09 Feb 2012 04:30 |
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