Effectiveness of exenatide in Asian Indians in clinical care setting

Sudhakaran, Chidambarann ; Fathima, Maryam ; Anjana, Ranjit Mohan ; Unnikrishnan, Ranjit I. ; Mohan, Viswanathan (2010) Effectiveness of exenatide in Asian Indians in clinical care setting Diabetes Technology & Therapeutics, 12 (8). pp. 613-618. ISSN 1520-9156

Full text not available from this repository.

Official URL: http://www.liebertonline.com/doi/abs/10.1089/dia.2...

Related URL: http://dx.doi.org/10.1089/dia.2010.0033

Abstract

Background: This study reports on the effectiveness of exenatide compared to insulin glargine or NPH insulin in patients with type 2 diabetes mellitus, unable to achieve glycemic control with oral glucose-lowering therapies in a clinical care setting. Patients and Methods: Patients with type 2 diabetes mellitus (n=47) whose glycemia was not controlled adequately with oral hypoglycemic agents at maximum recommended therapeutic doses were initiated on exenatide therapy. Age-, sex-, and body mass index-matched patients receiving insulin glargine (n=54) or NPH insulin (n=23) served as controls. Data analysis included glycated hemoglobin, fasting and postprandial plasma glucose, lipid profile, body weight, and the occurrence of hypoglycemia. Results: A statistically significant reduction in glycated hemoglobin value was noted after initiating exenatide (pre-exenatide 9.7±1.4% vs. post-exenatide 8.7±1.5%; P<0.05), which was comparable to values after insulin glargine (9.8±1.1% vs. 9.0±1.5%, respectively; P<0.05) and NPH insulin (9.6±1.4% vs. 8.9±1.3%, respectively; P<0.05). Exenatide therapy was associated with net weight loss (mean, 1.6kg), but therapy with insulin glargine and NPH insulin was associated with weight gain (1.8 and 2.3kg, respectively). Conclusions: In a group of select Asian Indian type 2 diabetes patients with secondary failure to oral hypoglycemic agents seen at a diabetes center, exenatide treatment in combination with oral drug regimens resulted in significant lowering of glycated hemoglobin similar to insulin glargine or NPH insulin but with the additional benefit of weight loss, albeit a small amount.

Item Type:Article
Source:Copyright of this article belongs to Mary Ann Liebert.
ID Code:81563
Deposited On:06 Feb 2012 03:42
Last Modified:06 Feb 2012 03:42

Repository Staff Only: item control page