Safa, Ashrafus ; Bhuiyan, Nurul A. ; Murphy, Denise ; Bates, John ; Nusrin, Suraia ; Kong, Richard Y. C. ; Chongsanguan, Manas ; Chaicumpa, Wanpen ; Balakrish Nair, G. (2009) Multilocus genetic analysis reveals that the Australian strains of Vibrio cholerae O1 are similar to the pre-seventh pandemic strains of the El Tor biotype Journal of Medical Microbiology, 58 (1). pp. 105-111. ISSN 0022-2615
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Official URL: http://jmm.sgmjournals.org/content/58/1/105.short
Related URL: http://dx.doi.org/10.1099/jmm.0.004333-0
Abstract
Episodes of cholera stemming from indigenous Vibrio cholerae strains in Australia are mainly associated with environmental sources. In the present study, 10 V. cholerae O1 strains of Australian origin were characterized. All of the strains were serogroup O1 and their conventional phenotypic traits categorized them as belonging to the El Tor biotype. Genetic screening of 12 genomic regions that are associated with virulence in V. cholerae showed variable results. Analysis of the ctxAB gene showed that the Australian environmental reservoir contains both toxigenic and non-toxigenic V. cholerae strains. DNA sequencing revealed that all of the toxigenic V. cholerae strains examined were of ctxB genotype 2. Whole genome PFGE analysis revealed that the environmental toxigenic V. cholerae O1 strains were more diverse than the non-toxigenic environmental O1 strains, and the absence of genes that make up the Vibrio seventh pandemic island-I and -II in all of the strains indicates their pre-seventh pandemic ancestry.
Item Type: | Article |
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Source: | Copyright of this article belongs to Society for General Microbiology. |
Keywords: | CCA; Chicken Blood Cell Agglutination MSHA; Mannose-sensitive Haemagglutinin VSP; Vibrio Seventh Pandemic Island |
ID Code: | 80591 |
Deposited On: | 01 Feb 2012 12:56 |
Last Modified: | 01 Feb 2012 12:56 |
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