Dutta, S. ; Iida, K. ; Takade, A. ; Meno, Y. ; Nair, G. B. ; Yoshida, S. (2004) Release of Shiga toxin by membrane vesicles in Shigella dysenteriae serotype 1 strains and in vitro effects of antimicrobials on toxin production and release Microbiology and Immunology, 48 (12). pp. 965-969. ISSN 0385-5600
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Official URL: http://www.jstage.jst.go.jp/browse/mandi/
Abstract
Effects of various antimicrobials on in vitro Shiga toxin production and release by Shigella dysenteriae serotype 1 was investigated in this study with particular reference to the role of outer membrane vesicles in toxin release by the organism. Five antimicrobials, namely nalidixic acid, ciprofloxacin, norfloxacin, fosfomycin and mitomycin C, were chosen for the study and the toxin titre was measured by the reverse passive latex agglutination (RPLA) method using an available kit. Only mitomycin C was found to induce production of Shiga toxin in the bacteria and its release by outer membrane vesicles. The highest titre of toxin was obtained in vesicle fraction suggesting that the vesicles play an important role in the release of Shiga toxin from periplasmic space by the organism.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Center for Academic Publications, Japan. |
| ID Code: | 80449 |
| Deposited On: | 01 Feb 2012 10:05 |
| Last Modified: | 01 Feb 2012 10:05 |
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