De, Keya ; Ramamurthy, Thandavarayan ; Faruque, Shah M. ; Yamasaki, Shinji ; Takeda, Yoshifumi ; Balakrish Nair, G. ; Nandy, Ranjan K. (2004) Molecular characterisation of rough strains of Vibrio cholerae isolated from diarrhoeal cases in India and their comparison to smooth strains FEMS Microbiology Letters, 232 (1). pp. 23-30. ISSN 0378-1097
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Official URL: http://onlinelibrary.wiley.com/doi/10.1016/S0378-1...
Related URL: http://dx.doi.org/10.1016/S0378-1097(04)00013-8
Abstract
Sixteen of the 18 Vibrio cholerae rough strains isolated from hospitalised diarrhoea patients were found to contain O1 serotype-specific (wbe) genes and all currently known virulence genes. Expression of the regulatory element ToxR was evident in these strains. Cholera toxin production ability of the rough strains was found to be higher (c. three- to five-fold) as compared to the smooth counterparts and this was transcriptionally regulated. Strains exhibiting the rough phenotype were more amenable to the uptake of CTXφ, which led us to consider that the rough phenotype could play a role in the generation of genetic diversity among V. cholerae strains.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Vibrio Cholerae; Rough Strain; Cholera Toxin |
| ID Code: | 80448 |
| Deposited On: | 01 Feb 2012 10:14 |
| Last Modified: | 01 Feb 2012 10:14 |
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