Wang, X. Y. ; Ansaruzzaman, M. ; Vaz, R. ; Mondlane, C. ; Lucas, M. E. ; von Seidlein, L. ; Deen, J. L. ; Ampuero, S. ; Puri, M. ; Park, T. ; Nair, G. B. ; Clemens, J. D. ; Chaignat, C. L. ; Rajerison, M. ; Nato, F. ; Fournier, J. M. (2006) Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population BMC Infectious Diseases, 6 (1). p. 17. ISSN 1471-233
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Official URL: http://www.biomedcentral.com/1471-2334/6/17/abstra...
Related URL: http://dx.doi.org/10.1186/1471-2334-6-17
Abstract
Background: Early detection of cholera outbreaks is crucial for the implementation of the most appropriate control strategies. Methods: The performance of an immunochromatographic dipstick test (Institute Pasteur, Paris, France) specific for Vibrio cholerae O1 was evaluated in a prospective study in Beira, Mozambique, during the 2004 cholera season (January-May). Fecal specimens were collected from 391 patients with acute watery nonbloody diarrhea and tested by dipstick and conventional culture. Results: The overall sensitivity and specificity of the rapid test compared to culture were 95% (95% confidence interval [CI]: 91%-99%) and 89% (95% CI: 86%-93%), respectively. After stratification by type of sample (rectal swab/bulk stool) and severity of diarrhea, the sensitivity ranged between 85% and 98% and specificity between 77% and 97%. Conclusion: This one-step dipstick test performed well in the diagnosis of V. cholerae O1 in a setting with seasonal outbreaks where rapid tests are most urgently needed.
Item Type: | Article |
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Source: | Copyright of this article belongs to BioMed Central. |
ID Code: | 80426 |
Deposited On: | 01 Feb 2012 12:50 |
Last Modified: | 18 May 2016 22:25 |
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