Talukder, Kaisar A. ; Khajanchi, Bijay K. ; Islam, Mohammad A. ; Islam, Zhahirul ; Dutta, Dilip K. ; Rahman, Mustafizur ; Watanabe, Haruo ; Nair, Gopinath B. ; Sack, David A. (2006) Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of shigella dysenteriae type 1 Current Microbiology, 52 (2). pp. 108-111. ISSN 0343-8651
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Official URL: http://www.springerlink.com/content/d7l71t5394mx77...
Related URL: http://dx.doi.org/10.1007/s00284-005-0140-9
Abstract
We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer. |
| ID Code: | 80423 |
| Deposited On: | 01 Feb 2012 12:49 |
| Last Modified: | 01 Feb 2012 12:49 |
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