Singaravel, M. ; Sharma, V. K. ; Subbaraj, R. ; Gopukumar Nair, N. (1996) Chronobiotic effect of melatonin following phase shift of light/dark cycles in the field mouse Mus booduga Journal of Biosciences, 21 (6). pp. 789-795. ISSN 0250-5991
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Official URL: http://www.ias.ac.in/jarch/jbiosci/21/789-795.pdf
Related URL: http://dx.doi.org/10.1007/BF02704720
Abstract
The objective of this study was to assess whether melatonin accelerates the re-entrainment of locomotor activity after 6 h of advance and delay phase shifts following exposure to LD 12:12 cycle (simulating jet-lag/shift work). An experimental group of adult male field mice Mus booduga were subjected to melatonin (1 mg/kg) through i.p. and the control group were treated with 50 % DMSO. The injections were administered on three consecutive days following 6h of phase advance and delay, at the expected time of "lights off". The results show that melatonin accelerates the re-entrainment after phase advance (29%) when compared with control mice. In the 6 h phase delay study, the experimental mice (melatonin administered) take more cycles for re-entrainment (51%) than the control. Further, the results suggest that though melatonin may be useful for the treatment of jet-lag caused by eastward flight (phase advance) it may not be useful for westward flight (phase delay) jet-lag.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Academy of Sciences. |
Keywords: | Melatonin; Re-entrainment; Circadian Rhythm; Locomotor Activity; Mus booduga |
ID Code: | 80399 |
Deposited On: | 31 Jan 2012 14:18 |
Last Modified: | 18 May 2016 22:24 |
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