Chopra, Vivek Sarojkumar ; Srinivasan, Arumugam ; Kumar, Ram Parikshan ; Mishra, Krishnaveni ; Basquin, Denis ; Docquier, Mylène ; Seum, Carole ; Pauli, Daniel ; Mishra, Rakesh Kumar (2008) Transcriptional activation by GAGA factor is through its direct interaction with dmTAF3 Developmental Biology, 317 (2). pp. 660-670. ISSN 0012-1606
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.ydbio.2008.02.008
Abstract
The GAGA factor (GAF), encoded by the Trithorax like gene (Trl) is a multifunctional protein involved in gene activation, Polycomb-dependent repression, chromatin remodeling and is a component of chromatin domain boundaries. Although first isolated as transcriptional activator of the Drosophila homeotic gene Ultrabithorax (Ubx), the molecular basis of this GAF activity is unknown. Here we show that dmTAF3 (also known as BIP2 and dTAFII155), a component of TFIID, interacts directly with GAF. We generated mutations in dmTAF3 and show that, in Trl mutant background, they affect transcription of Ubx leading to enhancement of Ubx phenotype. These results reveal that the gene activation pathway involving GAF is through its direct interaction with dmTAF3.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | GAGA Factor; GAF; Trithorax Like; Trithorax Group; Polycomb Group; BIP2; BTB/POZ Domain; dTAFII155; dmTAF3 |
| ID Code: | 79969 |
| Deposited On: | 30 Jan 2012 05:50 |
| Last Modified: | 30 Jan 2012 05:50 |
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