Pramanik, Dipankar ; Majeti, Bharat K. ; Mondal, Goutam ; Karmali, Priya P. ; Sistla, Ramakrishna ; Ramprasad, Obula G. ; Srinivas, Gunda ; Pande, Gopal ; Chaudhuri, Arabinda (2008) Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic α5β1 integrin receptor and mouse tumor vasculature Journal of Medicinal Chemistry, 51 (22). pp. 7298-7302. ISSN 0022-2623
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jm800915y
Related URL: http://dx.doi.org/10.1021/jm800915y
Abstract
Integrins, the major class of αβ heterodimeric transmembrane glycoprotein receptors, play crucial roles in mediating tumor angiogenesis. Genetic ablation experiments combined with use of antibodies/peptide ligands for blocking either α5 or β1 integrins have convincingly demonstrated α5β1 integrin to be unquestionably proangiogenic among the 24 known integrin receptors. Herein, we report on a novel RGDK-lipopeptide 1 that targets selectively α5β1 integrin and is capable of targeting genes to mouse tumor vasculatures.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 7992 |
| Deposited On: | 25 Oct 2010 09:35 |
| Last Modified: | 31 Jan 2011 08:08 |
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