Application of ultrasound-tagged photons for measurement of amplitude of vibration of tissue caused by ultrasound: theory, simulation, and experiments

Usha Devi, C. ; Vasu, R. M. ; Sood, A. K. (2006) Application of ultrasound-tagged photons for measurement of amplitude of vibration of tissue caused by ultrasound: theory, simulation, and experiments Journal of Biomedical Optics, 11 (3). No pp. given. ISSN 1083-3668

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Official URL: http://link.aip.org/link/?JBOPFO/11/034019/1

Related URL: http://dx.doi.org/10.1117/1.2209012

Abstract

We investigate the modulation of an optical field caused by its interaction with an ultrasound beam in a tissue mimicking phantom. This modulation appears as a modulation in the intensity autocorrelation, which is measured by a photon counting correlator. The factors contributing to the modulation are: 1. amplitude of vibration of the particles of the tissue, 2. refractive index modulation, and 3. absorption coefficient in the region of the tissue intercepted by the ultrasound beam and light. We show in this work that a significant part of the contribution to this modulation comes from displacement of the tissue particles, which in turn is governed by the elastic properties of the tissue. We establish, both through simulations and experiments using an optical elastography phantom, the effects of the elasticity and absorption coefficient variations on the modulation of intensity autocorrelation. In the case where there is no absorption coefficient variation, we suggest that the depth of modulation can be calibrated to measure the displacement of tissue particles that, in turn, can be used to measure the tissue elasticity.

Item Type:Article
Source:Copyright of this article belongs to The International Society for Optical Engineering.
Keywords:Biomedical Measurement; Biomedical Ultrasonics; Biomechanics; Vibration Measurement; Phantoms; Photon Counting; Elasticity; Refractive Index; Absorption Coefficients; Bio-optics; Optical Correlation; Biological Effects of Acoustic Radiation; Ultrasound-assisted Optical Tomography; Elastography; Optical Tomography; Medical Imaging
ID Code:79882
Deposited On:30 Jan 2012 05:03
Last Modified:30 Jan 2012 05:03

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