Srinivas, Ramishetti ; Karmali, Priya P. ; Pramanik, Dipankar ; Garu, Arup ; Mahidhar, Yenugonda Venkata ; Majeti, Bharat K. ; Ramakrishna, Sistla ; Srinivas, Gunda ; Chaudhuri, Arabinda (2010) Cationic amphiphile with shikimic acid headgroup shows more systemic promise than its mannosyl analogue as DNA vaccine carrier in dendritic cell based genetic immunization Journal of Medicinal Chemistry, 53 (3). pp. 1387-1391. ISSN 0022-2623
Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/jm901295s
Related URL: http://dx.doi.org/10.1021/jm901295s
Abstract
Mannosylated cationic vectors have been previously used for delivering DNA vaccines to antigen presenting cells (APCs) via mannose receptors expressed on the cell surface of APCs. Here we show that cationic amphiphiles containing mannose-mimicking quinic acid and shikimic acid headgroups deliver genes to APCs via mannose receptor. Cationic amphiphile with shikimic acid headgroup was more efficacious than its mannosyl counterpart in combating mouse tumor growth by dendritic cell (the most professional APC) based genetic immunization.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 7987 |
| Deposited On: | 25 Oct 2010 09:33 |
| Last Modified: | 31 Jan 2011 08:01 |
Repository Staff Only: item control page
