Srinivas, Ramishetti ; Samanta, Sanjoy ; Chaudhuri, Arabinda (2010) Cationic amphiphiles: promising carriers of genetic materials in gene therapy Chemical Society Reviews, 38 (12). 3326 - 3338. ISSN 0306-0012
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Official URL: http://www.rsc.org/publishing/journals/CS/article....
Related URL: http://dx.doi.org/10.1039/b813869a
Abstract
The clinical success of gene therapy critically depends on the use of efficient and safe gene delivery reagents. The present tutorial review is aimed at inspiring young researchers and students to take up the unsolved challenges in using cationic amphiphiles as safe gene transfer reagents. The review highlights important structure-activity studies in the field to date including the use of cationic amphiphiles for receptor specific targeted gene therapy and for delivery of siRNAs in the emerging field of RNA interference.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| Keywords: | Biochemistry; Review; Structure-activity Relationship; Pharmacology; Medicinal Chemistry; Vaccines; Serums |
| ID Code: | 7960 |
| Deposited On: | 25 Oct 2010 09:27 |
| Last Modified: | 31 Jan 2011 07:56 |
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