Gambhir, Deepali ; Lawrence, Able ; Aggarwal, Amita ; Misra, Ramnath ; Mandal, Sudhir Kumar ; Naik, Sita (2010) Association of tumor necrosis factor alpha and IL-10 promoter polymorphisms with Rheumatoid arthritis in North Indian population Rheumatology International, 30 (9). pp. 1211-1217. ISSN 0172-8172
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Official URL: http://www.springerlink.com/content/qk8l4262h6v537...
Related URL: http://dx.doi.org/10.1007/s00296-009-1131-0
Abstract
Rheumatoid arthritis is a chronic autoimmune disorder associated with altered expression of pro- and anti-inflammatory cytokines in the affected tissues. The aim of this study was to investigate the association between promoter polymorphisms of TNFα and IL-10 gene with susceptibility, age of disease onset and disease severity in North Indian patients with rheumatoid arthritis (RA). SNPs at position -308 and -863 of TNF gene and -819/-592 and -1082 position of IL-10 gene were determined in 222 patients and 208 healthy controls using RFLP or ARMS method. Polymorphism TNF -308A was less prevalent among the patients (1.7%) than controls (4.9%; p = 0.01, OR: 0.32, 95% CI: 0.13-0.76). Among female patients, IL-10 -592A allele associated with higher baseline disease activity scores (5.77 ± 1.99) than -592C (5.57 ± 1.19; p = 0.04). Female patients carrying allele A of TNFα -863 had earlier age of onset of RA (33.99 ± 9.6 years) than those with allele C (36.15 ± 11.21 years; p = 0.043). In conclusion, allele A at TNFα -308 locus provides protection against RA in North Indian population while another TNF allele A at -863 position had weak association with earlier onset of disease in female patients. On the other hand promoter polymorphisms of IL-10 did not affect susceptibility but polymorphism at -819/-592A was associated with higher disease activity scores at baseline.
Item Type: | Article |
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Source: | Copyright of this article belongs to Springer. |
Keywords: | Cytokines; IL-10; Polymorphisms; Rheumatoid Arthritis; TNF Alpha |
ID Code: | 79459 |
Deposited On: | 27 Jan 2012 14:30 |
Last Modified: | 27 Jan 2012 14:30 |
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