Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds

Mishra, Beena ; Priyadarsini, K. I. ; Mohan, Hari ; Mugesh, G. (2006) Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds Bioorganic & Medicinal Chemistry Letters, 16 (20). pp. 5334-5338. ISSN 0960-894X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bmcl.2006.07.085

Abstract

Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride (EbTe2) with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of EbTe2, the inhibitory effect on γ-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of EbTe2.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Ebselen; Antioxidant; Selenium; Horseradish Peroxidase; Lipid Peroxidation
ID Code:79324
Deposited On:25 Jan 2012 06:09
Last Modified:25 Jan 2012 06:09

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