Tamilselvi, A. ; Mugesh, Govindasamy (2009) Inhibition of peroxidase-catalyzed iodination by cephalosporins: metallo-β-lactamase-induced antithyroid activity of antibiotics ChemMedChem, 4 (4). pp. 512-516. ISSN 1860-7179
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/cmdc.20...
Related URL: http://dx.doi.org/10.1002/cmdc.200800371
Abstract
Broad-spectrum antibiotics with heterocyclic side chains strongly inhibit peroxidase-catalyzed iodination in the presence of metallo-β-lactamase. This suggests that antibiotic resistance due to hydrolysis of the β-lactam ring in antibiotics would have negative effects on thyroid activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Antibiotics; Antithyroid Drugs; Drug Resistance; Metallo-β-lactamase; Peroxidase |
| ID Code: | 79308 |
| Deposited On: | 25 Jan 2012 06:33 |
| Last Modified: | 25 Jan 2012 06:33 |
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