Ali, Amjad ; Flora, Swaran J. S. ; Saxena, Geetu ; Kolehmainen, Erkki ; Mahieu, Bernard ; Rao, Chebrolu P. (2006) Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidative stress and essential metal concentration in lead exposed male Wistar rats Journal of Inorganic Biochemistry, 100 (2). pp. 206-213. ISSN 0162-0134
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.jinorgbio.2005.11.008
Abstract
The two Sn(IV) complexes synthesized using calix[4]arene-1,3-di-acid derivative were characterized by analytical, 1H, 13C and 119Sn NMR, matrix assisted laser desorption ionization mass, and 119Sn Mossbauer techniques and found that the complexes are tetranuclear possessing structurally two different types of tin centers. These complexes were evaluated for their protective value against blood and tissue oxidative stress in lead exposed male albino rats of Wistar strain. The results suggest that the two tin complexes significantly protect changes in lead induced biochemical variables indicative of heme synthesis pathway and exhibit only moderate effect on tissue oxidative stress. The beneficial effects could be attributed mainly to the ability of Sn(IV) complexes in preventing absorption of lead to the target sites/tissues.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | p-tert-Butyl-calix[4]arene-1,3-diacid; Tetranuclear Tin Complexes; Reversal of Lead Toxicity in Wistar Rats; Hematological Parameters; Hepatic and Renal Soft Tissue |
ID Code: | 79166 |
Deposited On: | 24 Jan 2012 15:27 |
Last Modified: | 19 Apr 2012 06:41 |
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