Ghosh, Amrita ; Das, Priyadip ; Gill, Martin R. ; Kar, Prasenjit ; Walker, Michael G. ; Thomas, Jim A. ; Das, Amitava (2011) Photoactive RuII-polypyridyl complexes that display sequence selectivity and high-affinity binding to duplex DNA through groove binding Chemistry - A European Journal, 17 (7). pp. 2089-2098. ISSN 0947-6539
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.20...
Related URL: http://dx.doi.org/10.1002/chem.201002149
Abstract
The duplex-DNA binding properties of a nonintercalating polypyridyl ruthenium(II) complex that incorporates a linear extended ligand with a catechol moiety has been probed with a variety of photo- and biophysical techniques. These studies reveal that the complex groove binds to DNA sequences biphasically, and displays binding constants equivalent to those of high-affinity metallointercalators. The complex also displays preferential binding to AT-rich sequences. Changes in the structure of the coordinated catechol ligand and the incorporation of intercalating ancillary ligands into the complex were found to modulate both the optical-binding response and binding parameters of the system, which indicates that the catechol moiety plays a crucial role in the observed enhancement to binding affinities.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons. |
Keywords: | DNA; Groove Binding; Luminescence; Molecular Recognition; Ruthenium |
ID Code: | 78517 |
Deposited On: | 20 Jan 2012 04:22 |
Last Modified: | 20 Jan 2012 04:22 |
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