Dhar, Shanta ; Reddy, Pattubala A. N. ; Chakravarty, Akhil R. (2004) Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridiquinoxaline)-copper(II) complex Dalton Transactions, 2004 (5). pp. 697-698. ISSN 1477-9226
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2004...
Related URL: http://dx.doi.org/10.1039/B401383B
Abstract
The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58±0.4 h-1 and a rate enhancement of 1.55×108.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 78274 |
| Deposited On: | 19 Jan 2012 06:40 |
| Last Modified: | 19 Jan 2012 06:42 |
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