Chakraborty, Tushar K. ; Ghosh, Animesh (2002) Synthesis of chiral α-amino acids Tetrahedron Letters, 43 . pp. 9691-9693. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02433-4
Abstract
A novel method for the synthesis of chiral α-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the α-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | α-amino Acids; Hofmann Rearrangement; Oxazolidinone; Evans' Reaction |
| ID Code: | 78259 |
| Deposited On: | 18 Jan 2012 12:14 |
| Last Modified: | 18 Jan 2012 12:14 |
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