Raman, G. ; Nagendranath, N. ; Munshi, S. R. ; Sheth, A. R. (1977) Testicular phosphatase activity in rats treated with cyproterone acetate & flutamide Indian Journal of Experimental Biology, 15 (9). pp. 788-790. ISSN 0019-5189
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Abstract
PIP: Cyproterone acetate (CPA) and flutamide (F), 2 antiandrogens were tested in the rat, to determine their effect on acid (ACP) and alkaline (ALP) phosphatase activity. 70 fertile male rats were injected with either CPA, F, or testosterone propionate (TP) at either 2.5 or 10 mg. TP was injected either alone or in combination with the others. Histological examinations of the testes were performed. Spermatogenesis was arrested and Leydig cells atrophied in animals treated with CPA or F. Histochemical examination revealed that CPA enhanced ALP and ACP in the testes while F decreased ALP and ACP. TP treatment in combination with either antiandrogens was unable to overcome their effect. The changes in the 2 phosphatases depending on which antiandrogen was injected suggests different modes of action.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| ID Code: | 78172 |
| Deposited On: | 18 Jan 2012 05:08 |
| Last Modified: | 18 Jan 2012 05:08 |
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