Seidah, N. G. ; Arbatti, N. J. ; Rochemont, J. ; Sheth, A. R. ; Chrétien, M. (1984) Complete amino acid sequence of human seminal plasma β-inhibin: prediction of post Gln-Arg cleavage as a maturation site FEBS Letters, 175 (2). pp. 349-355. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(84)80766-8
Abstract
The complete sequence of a 94 amino acid human seminal plasma polypeptide exhibiting inhibin-like activity is presented. This molecule, called β-inhibin, selectively and specifically suppresses the release of pituitary FSH in vivo as well as in vitro. It does not affect the secretion of LH. Such a novel acidic protein contains a very basic C-terminal segment which is easily cleaved by mild tryptic digestion. It is predicted that the FSH inhibiting activity may reside within this region of the molecule. This would imply a post Gln-Arg cleavage to release the basic C-terminal active moiety.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | β-inhibin; Pituitary FSH Release; Amino Acid Sequence; Human Seminal Plasma |
| ID Code: | 78095 |
| Deposited On: | 17 Jan 2012 10:19 |
| Last Modified: | 17 Jan 2012 10:19 |
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