Inhibin: unity in diversity

Abstract

Historically, inhibin was thought to be a testicular hormone involved in the regulation of pituitary FSH by a negative feedback control. The ability of inhibin to preferentially suppress FSH without affecting LH triggered extensive research for its possible use as a male contraceptive, suggesting a plurality of molecular forms and a multiplicity of biological actions of this putative hormone. It also became evident that inhibin is not unique to the testis, as presumed earlier, and can even be obtained from the ovary. This has necessitated a fundamental revision of the original concept of inhibin. Unfortunately, not many perceive inhibin as a loose conglomerate of structurally dissimilar, FSH-suppressing proteins and insist on singling out a 32-kDa protein derived from ovarian follicular fluid to be designated as inhibin. This article highlights features common to two distinctly different types of inhibin: seminal inhibin and ovarian inhibin. Evidence is also provided to indicate that the term inhibin need not be specific to the ovarian protein, but encompasses proteins hitherto dismissed as inhibin-like or inhibin-related proteins.